Allergen360

Measures immune response to allergens with treatment monitoring markers

Allergen360 detects up to four biomarkers for each allergen to determine hypersensitivities and other inflammatory responses.

More than 50 million Americans suffer from chronic allergies

Allergen360 Panels

Allergen360 is a proprietary laboratory test that measures the immune response to allergens. Unlike traditional allergy testing that is limited to IgE, we uniquely detect IgE, IgG4 and C3D biomarkers to help determine type I and type III hypersensitivities, and total IgG for inflammatory responses.

Environmental Allergens

Allergen360 Environmental panels detect IgE reactivity to environmental allergens that are inhaled or contacted. The higher the value the greater the potential risk of an allergic reaction. It also detects the immune reactivity from exposure to allergens and how IgG4 competes with IgE for binding sites on specific allergens. The detection of these exposures can be used to establish baselines of hypersensitivity to specific allergen(s) as well as be used as a tool to manage the clinical efficacy of immunotherapy for the neutralization of offending IgE species.

Food Allergens

Allergen360 Dietary panels detect IgE allergic reactivity and sensitivities. It also monitors the immune reactivity of IgG4 that competes with IgE for binding sites on specific allergen(s). IgE usually occurs immediately and can create severe symptoms such as swelling, hives, itching, and in worst cases - anaphylaxis.
You May Not Know
Food allergies cause respiratory symptoms.

Allergies are the most common chronic disorder in children.

Food allergy is a problem of epidemic proportions

60% of Americans suffer from unsuspected food reactions

About 32 million Americans have food allergies
Every three minutes a food allergy reaction sends someone to the emergency room
Each year 200,000 Americans require emergency medical care for allergic reactions to food
Every year food allergies cost about $25 billion in treatment and loss in productivity

Better Information for Confident Decisions

We deliver fast and accurate results with unique information and insights to better match the right patient to the right treatment.
IgE
The IgE antibody response is the most commonly known allergen response. IgE reactions stimulate the release of histamine in the body. The results of IgE may indicate if a patient has a Type I hypersensitivity (or immediate hypersensitivity) which is an allergic reaction provoked by exposure to an allergen (environmental or food). The presence of allergy related symptoms confirms IgE allergy.
IgG4 and Blocking Potential
IgG4 is a subclass of IgG and comprises only 4% of IgG antibodies. IgG4 serves as an indicator of the extent of allergen exposure and are produced after long-term exposure to an antigen. 1 IgG4 total antibody is important in relation to IgE because this antibody acts as a blocking agent for an IgE reaction. 2,3 When the IgG4 reaction is greater than the IgE reaction for a particular antigen, IgG4 may block the IgE antibodies from binding to the receptor sites and releasing histamine, thereby reducing the severity of the symptoms associated with the IgE reaction. This is referred to as the Blocking Potential. Higher IgG4 improves the odds of neutralization IgE reactivity and prevents allergen specific adverse reactions from occurring. The blocking potential value to specific allergens must be used in conjunction with the patient’s symptoms. Furthermore, IgG4 may also be used to manage the clinical efficacy of immunotherapy for the neutralization of IgE reactions. 3 IgG4 antibodies not only block IgE mediated allergies but also block the reactions of other IgG subclasses, reducing inflammatory reactions caused by other IgG subclasses.
C3D
C3D is a complement antigen and an activator of our complement cascade system. Reaction to the specified food will worsen if C3D activation is present. 10 The C3 protein attaches to the antigen and amplifies the IgG response, increasing the inflammatory potential of IgG titer. The results of C3D may determine Type III hypersensitivity when there is accumulation of immune complexes (antigen-antibody complexes) that have not been adequately cleared by innate immune cells, giving rise to an inflammatory response.
IgG
IgG immune complexes can be deposited in tissues, leading to inflammation. IgG1, IgG2, and IgG3 all are capable of causing inflammation because they activate complement, resulting in an inflammatory cascade that is associated with IBS, IBD, eczema, migraines, autism, anxiety, depression, and obesity. 4,5,6,7,8,9 However, there’s a fourth IgG subclass - IgG4 - that does not bind to complement and therefore does not trigger inflammation. Confusion about dietary allergy and dietary intolerance or inflammation can cause misinterpretation. A IgG reaction is different than an immediately life-threatening food allergy (IgE). IgG is the most abundant circulating antibody in our immune system, can cause a delayed immune reaction and they are never life threatening.

How to Implement into Clinical Care

Monitoring

Use to detect the efficacy of immunotherapy. By monitoring IgG4 levels, you gain early insights to predict treatment success.

Diagnosis

Determine if allergies are the cause of your patient’s respiratory, gastrointestinal and other inflammatory symptoms.

Citations and Footnotes:

  1. Collins AM, Jackson KJL. A temporal model of human IgE and IgG antibody function. Front Immunol. 2013 Aug 9;4:235.
  2. Till SJ, Francis JN, Nouri-Aria K, Durham SR. Mechanisms of immunotherapy. J Allergy Clin Immunol. 2004 Jun;113(6):1025-34;quiz 1035.
  3. Akdis CA, Akdis M. Mechanisms of allergen-specific immunotherapy and immune tolerance to allergens. World Allergy Organ J. 2015 May 14;8(1):17.
  4. W. Atkinson, et al Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial. Gut 2004;53:1459-1464.
  5. Bentz S,Clinical relevance of IgG antibodies against food antigens in Crohn's disease: a double-blind cross-over diet intervention study. Digestion.   2010;81(4):252-64. Epub 2010 Jan 30.
  6. Huber A,et alInt Arch Allergy Immunol. 1998 Jan; 115(1):67-72. Diet restriction in migraine, based on IgG against foods: a clinical double-blind, randomised,  cross-over trial.
  7. Wilders-Truschnig M et al. IgG Antibodies Against Food Antigens are Correlated with Infl ammation and Intima Media Thickness in Obese Juveniles. Exp Clin     Endocrinol Diabetes DOI 10.1055/s-2007-993165.  Published online: 2007.
  8. Tahmeed Ahmed; et al Circulating antibodies to common food antigens in Japanese children with IDDM. Diabetes Care; Jan 1997; 20, 1; Research Library, pg.  74-76.
  9. O’Farrelly, C., Price, R., McGillivray, A.J. and Fernandes, L. (1989), IgA rheumatoid factor and IgG dietary protein antibodies are associated in rheumatoid arthritis,  Immunological Investigations, Vol. 18, pp.  
       753-64.
  10. Pepys MB . Role of complement in induction of the allergic response. Nat New Biol 1972; 237:157–159.
  11. James JM. Respiratory manifestations of food allergy. Pediatrics. 2003 Jun;111(6 Pt 3):1625–30.